• About
  • Keywords

Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

type-2

Maternal infections and subsequent psychosis among offspring

November 7, 2001
Buka, S.L., Tsuang, M.T., Torrey, E.F., Klebanoff, M.A., Bernstein, D., Yolken, R.H.
ArchGenPsychiatry 2001 Nov;58(11):1032-7 2001
Click for abstract
Background: We tested the hypothesis that maternal infections during pregnancy are associated with the subs equent development of schizophrenia and other psychoses in adulthood. Methods: We conducted a nested case-control study of 27 adults with schizophrenia and other psychotic illnesses and 54 matched unaffected control subjects (matched for sex, ethnicity, and date of birth) from the Providence, RI, cohort of the Collaborative Perinatal Project. We retrieved stored blood samples that had been obtained from these mothers at the end of pregnancy. These samples were analyzed for total class-specific immunoglobulins and for specific antibodies directed at recognized perinatal pathogens capable of affecting brain development. Results: Maternal levels of IgG and IgM class immunoglobulins before the mothers were delivered of their neonates were significantly elevated among the case series (t=3.06, P=.003; t=2.93, P=.004, respectively, for IgG and IgM immunoglobulin-albumin ratios). Secondary analyses indicated a significant association between maternal antibodies to herpes simplex virus type 2 glycoprotein gG2 and subsequent psychotic illness (matched t test=2.43, P=.02). We didn't find significant differences between case and control mothers in the serum levels of IgA class immunoglobulins, or in specific IgG antibodies to herpes simplex Virus type 1, cytomegalovirus, Toxoplasma gondii, rubella virus, human parvovirus B19, Chlamydia trachomatis, or human papillomavirus type 16. Conclusions: The offspring of mothers with elevated levels of total IgG and IgM immunoglobulins and antibodies to herpes simplex virus type 2 are at increased risk for the development of schizophrenia and other psychotic illnesses in adulthood.

Tagged: adult schizophrenia, bipolar disorder, collaborative perinatal project, encephalitis, follow-up, herpes-simplex-virus, influenza, pregnancy, prenatal exposure, type-2

Mental health

Topics

  • Behavior 105
  • Cognitive functions 64
  • Mental health 439
  • Morphology 6
  • Motor functions 10
  • Personality 36
  • Physical health 134
  • Reproduction 36
  • Reviews 40
  • Sensory functions 3
  • Uncategorized 2

Archives

Recent articles

  • Mortality Patterns of Toxoplasmosis and Its Comorbidities in Tanzania: A 10-Year Retrospective Hospital-Based Survey February 6, 2020
  • The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia–the risk factor or an indication of a contact with cat? February 6, 2020
  • The Association between Toxoplasma gondii Infection and Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis February 6, 2020

Recent Comments

  • forum posting backlinks on Diagnostic problems in psychiatry with regard to acquired toxoplasmosis
  • 소액결제창업교육 on Diagnostic problems in psychiatry with regard to acquired toxoplasmosis
  • https://dp73.spb.ru/news-1058559-razbor-akkordov-na-gitare.html on Diagnostic problems in psychiatry with regard to acquired toxoplasmosis
  • invest on Diagnostic problems in psychiatry with regard to acquired toxoplasmosis
  • press release writing software on Diagnostic problems in psychiatry with regard to acquired toxoplasmosis

Meta

  • Log in
  • Entries feed
  • Comments feed
  • WordPress.org

Copyright © 2022 Toxoplasma gondii & Human Phenotype.

ToxoBehavior WordPress Theme by Jelena Braum