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Context: Toxoplasma gondii is a protozoan parasite with a world-wide distribution. However, the majority of infected cases remain symptomless. There are raising scientific evidences indicating that parasitic infections induce antitumor activity against certain types of cancers. The inhibitory effect of T. gondii on cancer growth has also been shown in cell culture and mouse model. Aims: Considering the anti-tumor effect of this parasite, in this study the relationship between low titer of antibodies against T. gondii and resistant to cancers has been investigated. Subjects and Methods: In two separate experiments, anti T. gondii antibody was estimated in 150 patients with cancer and 120 normal people. Statistical Analysis Used: Chi-square test was used for data analysis. Results: The frequency of low titer antibody against Toxoplasma gondii in cancer patients was significantly higher than the frequency of low-titer antibody against this parasite in normal people. Conclusions: Exposure to T. gondii may be related to resistance to cancer.