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Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

schiizophrenia

Genome-wide association study (GWAS) of Toxoplasma gondii infection and evaluation of schizophrenia risk by using a polygenic risk score (PRS)

October 2, 2017 10 Comments
Lori, A., Avramopoulos, D., Wang, A., Goes, F. S., Mulle, J., Powers, A., McGrath, J. J., Massa, N., Weng, L., Duncan, E., Nestadt, G., Conneely, K., Wolyniec, P., Wang, R., Hopkins, M., Ruczinski, I., Yolken, R., Jovanovic, T., Ressler, K., Pulver, A. E., Pearce, B. D.
Biological Psychiatry 2017; 81: S371-S371
Click for abstract
Toxoplasma gondii (TOXO) infects approximately 1.5 billion people worldwide. TOXO is implicated in a heightened risk for schizophrenia (SCZ). We performed a GWAS with TOXO in an Ashkenazi cohort of SCZ subjects. We then applied the schizophrenia polygenic risk score (SCZ-PRS) derived from the Psychiatric GWAS Consortium separately in TOXO-positive and TOXO-negative subjects to explore the hypothesis that SCZ subjects infected by TOXO will have less polygenic risk burden than uninfected subjects.

Tagged: gwas, polygenic risk score, schiizophrenia, Toxoplasma gondii

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