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Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

responses

Is Toxoplasma gondii playing a positive role in multiple sclerosis risk? A systematic review and meta-analysis

August 31, 2018
Saberi, R., Sharif, M., Sarvi, S., Aghayan, S. A., Hosseini, S. A., Anvari, D., Chegeni, T. N., Hosseininejad, Z., Daryani, A.
Journal of Neuroimmunology 2018;322: 57-62
Click for abstract
Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii with a globally widespread distribution. The aim of this systematic review and meta-analysis was to characterize the association between T. gondii infection and multiple sclerosis (MS). The data were systematically collected from the English electronic databases up to April 2017. The research process resulted in the identification of five studies related to the subject of interest entailing 669 MS patients and 770 controls. The pooled prevalence rates of T. gondii infection in the MS patients and controls were estimated as 32.4% (95% CI: 27.4-38.6) and 39.1% (95% CI: 29.1-50.5), respectively. By random effect model, the combined odds ratio was 0.72 (95% CI: 0.49-1.06) with P = .0961. Although this meta-analysis study showed a lower seroprevalence of T. gondii in the MS patients as compared with that in the control group, no significant association was found between toxoplasmosis and MS disease. Further investigations are recommended to determine the detailed association between MS patients and T. gondii infection.

Tagged: antibodies, autoimmune, brain-development, diseases, family-members, hygiene hypothesis, infection, meta-analysis, multiple sclerosis, Parasite, responses, Schizophrenia, systematic review, Toxoplasma gondii

Physical health

The relation of cortisol and sex hormone levels to results of psychological, performance, IQ and memory tests in military men and women

January 9, 2012
Flegr, J., Hampl, R., Černochová, D., Preiss, M., Bičíkova, M., Sieger, L., Příplatová, L., Kaňková, S., Klose, J.
Neuroendocrinology Letters 2012; 33: 224-235
Click for abstract
BACKGROUND: Cortisol, along with other hormones of hypothalamo-pituitary-adrenal axis, belongs to one of the main factors influencing psychological and pathognomic factors, intelligence, and memory. METHODS: The aim of our study was to review a large battery of psychological, performance, IQ and memory tests as to their relation with cortisol, testosterone and estrogen levels in groups of 100 men and 93 women who attended the Central Military Hospital in Prague for regular entrance psychological examinations for military personnel. RESULTS: In men, we detected positive correlations between cortisol and emotional lability, and negative correlations with impulsivity, while in women hypochondria and psychopathology were negatively correlated, and aggression measured with the Meili selective memory test had a positive relation to cortisol level. Testosterone correlated positively with emotional liability and negatively with impulsivity in men, and negatively with hypochondria and psychasteny, indirect aggression, irritability and paranoia in women. Estradiol correlated positively with psychopathology in men, and negatively with phobia. It was positively correlated with negativism in women. No clear correlation was observed between the concentration of steroid hormones and psychomotor performance or intelligence. CONCLUSIONS: Concentrations of steroid hormones correlate with results of several psychological tests, the sign and magnitude of these correlations, however, very often differ in military men and women.

Tagged: aggression, bdi, behavior, cortisol, dominance, estrogen, gender differences, hypothesis, intelligence, meili test, memory, miller 2009, n-70, od-1, otis test, personality, personality tests, psychology, questionnaire, responses, stress, supports, testosterone, testosterone concentration, topp, toxoplasmosis, wmt

Cognitive functionsPersonality

Topics

  • Behavior 105
  • Cognitive functions 64
  • Mental health 439
  • Morphology 6
  • Motor functions 10
  • Personality 36
  • Physical health 134
  • Reproduction 36
  • Reviews 40
  • Sensory functions 3
  • Uncategorized 2

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Recent articles

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  • The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia–the risk factor or an indication of a contact with cat? February 6, 2020
  • The Association between Toxoplasma gondii Infection and Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis February 6, 2020

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