• About
  • Keywords

Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

ptsd

Relationship between Toxoplasma gondii seropositivity and acoustic startle response in an inner-city population

October 2, 2017 26 Comments
Massa, N. M., Duncan, E., Jovanovic, T., Kerley, K., Weng, L., Gensler, L., Lee, S. S., Norrholm, S., Powers, A., Almli, L. M., Gillespie, C. F., Ressler, K., Pearce, B. D.,
Brain Behavior and Immunity 2017; 61: 176-183
Click for abstract
Toxoplasma gondii (TOXO) is a neuroinvasive protozoan parasite that induces the formation of persistent cysts in mammalian brains. It infects approximately 1.1 million people in the United States annually. Latent TOXO infection is implicated in the etiology of psychiatric disorders, especially schizophrenia (SCZ), and has been correlated with modestly impaired cognition. The acoustic startle response (ASR) is a reflex seen in all mammals. It is mediated by a simple subcortical circuit, and provides an indicator of neural function. We previously reported the association of TOXO with slowed acoustic startle latency, an index of neural processing speed, in a sample of schizophrenia and healthy control subjects. The alterations in neurobiology with TOXO latent infection may not be specific to schizophrenia. Therefore we examined TOXO in relation to acoustic startle in an urban, predominately African American, population with mixed psychiatric diagnoses, and healthy controls. Physiological and diagnostic data along with blood samples were collected from 364 outpatients treated at an inner-city hospital. TOXO status was determined with an ELISA assay for TOXO-specific IgG. A discrete titer was calculated based on standard cut-points as an indicator of seropositivity, and the TOXO-specific IgG concentration served as serointensity. A series of linear regression models were used to assess the association of TOXO seropositivity and serointensity with ASR magnitude and latency in models adjusting for demographics and psychiatric diagnoses (PTSD, major depression, schizophrenia, psychosis, substance abuse). ASR magnitude was 11.5% higher in TOXO seropositive subjects compared to seronegative individuals (p = 0.01). This effect was more pronounced in models with TOXO serointensity that adjusted for sociodemographic covariates (F = 7.41, p = 0.0068; F = 10.05, p = 0.0017), and remained significant when psychiatric diagnoses were stepped into the models. TOXO showed no association with startle latency (t = 0.49, p = 0.63) in an unadjusted model, nor was TOXO associated with latency in models that included demographic factors. After stepping in individual psychiatric disorders, we found a significant association of latency with a diagnosis of PTSD (F = 5.15, p = 0.024), but no other psychiatric diagnoses, such that subjects with PTSD had longer startle latency. The mechanism by which TOXO infection is associated with high startle magnitude is not known, but possible mechanisms include TOXO cyst burden in the brain, parasite recrudescence, or molecular mimicry of a host epitope by TOXO. Future studies will focus on the neurobiology underlying the effects of latent TOXO infection as a potential inroad to the development of novel treatment targets for psychiatric disease.

Tagged: acoustic startle response, association, bipolar disorder, human personality, infection, latent toxoplasmosis, mental health, posttraumatic-stress-disorder, prepulse inhibition, ptsd, risk factors, Schizophrenia, substance use disorder, Toxoplasma gondii, united-states

Cognitive functionsMotor functions

Topics

  • Behavior 105
  • Cognitive functions 64
  • Mental health 439
  • Morphology 6
  • Motor functions 10
  • Personality 36
  • Physical health 134
  • Reproduction 36
  • Reviews 40
  • Sensory functions 3
  • Uncategorized 2

Archives

Recent articles

  • Mortality Patterns of Toxoplasmosis and Its Comorbidities in Tanzania: A 10-Year Retrospective Hospital-Based Survey February 6, 2020
  • The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia–the risk factor or an indication of a contact with cat? February 6, 2020
  • The Association between Toxoplasma gondii Infection and Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis February 6, 2020

Recent Comments

  • buy hydroxychloroquine 200mg on Bipolar disorder with psychotic features and ocular toxoplasmosis
  • Escorts Service Near Aerocity Riya Call Whatsapp Aerocity Call Girl on Diagnostic problems in psychiatry with regard to acquired toxoplasmosis
  • Escorts Service Near Niti Khand Riya Call Whatsapp Niti Khand Call Girl on Diagnostic problems in psychiatry with regard to acquired toxoplasmosis
  • Escorts Service Near Nangli Wazidpur Sector 135 Riya Call Whatsapp Nangli Wazidpur Sector 135 Call Girl on Diagnostic problems in psychiatry with regard to acquired toxoplasmosis
  • buy hydroxychloroquine 200mg on Seroprevalence of Toxoplasma gondii infection in cancer patients: A systematic review and meta-analysis

Meta

  • Log in
  • Entries feed
  • Comments feed
  • WordPress.org

Copyright © 2022 Toxoplasma gondii & Human Phenotype.

ToxoBehavior WordPress Theme by Jelena Braum