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Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

protozoan/analysis

Incidence of toxoplasmosis in patients with cirrhosis

October 30, 2004
Ustun, S., Aksoy, U., Dagci, H., Ersoz, G.
World Journal of Gastroenterology 2004; 10: 452-454.
Click for abstract
AIM: It is known that toxoplasmosis rarely leads to various liver pathologies, most common of which is granulomatose hepatitis in patients having normal immune systems. Patients who have cirrhosis of the liver are subject to a variety of cellular as well as humoral immunity disorders. Therefore, it may be considered that toxoplasmosis can cause more frequent and more severe diseases in patients with cirrhosis and is capable of changing the course of the disease. The aim of this study was to investigate the frequency of toxoplasmosis in patients with cirrhosis. METHODS: Serum samples were taken from 108 patients with cirrhosis under observation in the Hepatology Polyclinic of the Gastroenterology Clinic, and a control group made up of 50 healthy blood donors. IFAT and ELISA methods were used to investigate the IgG and IgM antibodies, which had developed from these sera. RESULTS: Toxoplasma IgG and IgM antibody positivity was found in 74 (68.5%) of the 108 cirrhotic patients and 24 (48%) of the 50 people in the control group. The difference between them was significant (P<0.05). CONCLUSION: In conclusion, it was found that the toxoplasma sero-prevalence in the cirrhotic patients in this study was higher. Cirrhotic patients are likely to form a toxoplasma risk group. More detailed studies are needed on this subject.

Tagged: adult, animals, antibodies, female, humans, incidence, male, middle aged, protozoan/analysis, Toxoplama, toxoplasmosis/comlications/immunology

Physical health

Investigation of probable relationship between Toxoplasma gondii and cryptogenic epilepsy

October 30, 2003
Yazar S, et al
Seizure-European Journal of Epilepsy 2003; 12: 107-109.
Click for abstract
PURPOSE: Cryptogenic epilepsy, defines a group of epilepsy syndromes for which an aetiology is unknown but an underlying brain disease is suspected. We selected patients in this subgroup of epilepsy and investigated the sero-positivity rate for anti-Toxoplasma IgG antibodies by Enzyme Linked Immunosorbent Assay (ELISA). We investigated the probable relationship between Toxoplasma gondii and cryptogenic epilepsy. METHODS: We selected 50 patients with cryptogenic epilepsy, 50 patients with known cause epilepsy and 50 healthy volunteers and investigated the sero-positivity rate for anti-Toxoplasma IgG antibodies by ELISA. RESULTS: The sero-positivity rate for anti-Toxoplasma IgG antibodies among cryptogenic epilepsy patients (52%) was found to be higher than healthy volunteers (18%) and known cause epilepsy patients (22%) with statistical significance, (X(2)=18.095, P<0.01). CONCLUSION: There might be a causal relationship between chronic toxoplasmosis and the aetiology of cryptogenic epilepsy

Tagged: animals, antibodies, cerebral/*parasitology, chronic disease, enzyme-linked immunosorbent assay, epilepsy/blood/*parasitology, humans, immunoglobulin G/analysis, protozoan/analysis, Toxoplasma/immunology/isolation & purification, toxoplasmosis

Physical health

Landau-Kleffner syndrome–epileptic aphasia in children–possible role of Toxoplasma gondii infection

November 8, 1988
Michaoowicz, R., Jozwiak, S., Ignatowicz, R., Szwabowska-Orzeszko, E.
Acta Paediatrica Hungarica 1988; 29: 337-342
Click for abstract
The association of unusual types of aphasia and epilepsy (Landau-Kleffner syndrome) has been described in three children. The children were 5 to 11 years of age and all have EEG abnormalities. Speech disorders appeared after epileptic seizures. No organic causes of the disease have been found in axial computed tomography. In all described cases the increased titer of IgG antibodies against Toxoplasma gondii has been observed. The authors suggest that the Toxoplasma gondii infection should be taken into account as a possible cause of Landau-Kleffner syndrome.

Tagged: antibodies, aphasia/*etiology, child, electroencephalography, epilepsy/*etiology, female, humans, immunoglobulin G/analysis, male, preschool, protozoan/analysis, syndrome, toxoplasmosis/*complications/immunology

Physical health

Toxoplasma seropositivity in patients with rheumatoid arthritis

November 8, 1988
Mousa, M. A., Soliman, H. E., el Shafie, M. S., Abdel-Baky, M. S., Aly, M. M.
Journal of the Egyptian Society of Parasitology 1988; 18: 345-351
Tagged: 80 and over, adolescent, adult, aged, animals, antibodies, arthritis, humans, middle aged, protozoan/analysis, rheumatoid/*complications, Toxoplasma/*immunology, toxoplasmosis/*complications

Physical health

Topics

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  • Uncategorized 2

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Recent articles

  • Mortality Patterns of Toxoplasmosis and Its Comorbidities in Tanzania: A 10-Year Retrospective Hospital-Based Survey February 6, 2020
  • The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia–the risk factor or an indication of a contact with cat? February 6, 2020
  • The Association between Toxoplasma gondii Infection and Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis February 6, 2020

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