polygenic risk score

Toxoplasma gondii (TOXO) infects approximately 1.5 billion people worldwide. TOXO is implicated in a heightened risk for schizophrenia (SCZ). We performed a GWAS with TOXO in an Ashkenazi cohort of SCZ subjects. We then applied the schizophrenia polygenic risk score (SCZ-PRS) derived from the Psychiatric GWAS Consortium separately in TOXO-positive and TOXO-negative subjects to explore the hypothesis that SCZ subjects infected by TOXO will have less polygenic risk burden than uninfected subjects.