parkinson’s disease

Parkinson’s disease and Toxoplasma gondii infection: Sero-molecular assess the possible link among patients

October 2, 2017
Fallahi, S., Rostami, A., Birjandi, M., Zebardast, N., Kheirandish, F., Spotin, A.
Acta Tropica 2017; 173: 97-101

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We investigated the possible association between Parkinson's disease (PD), the second most common neurode-generative disorder and Toxoplasma gondii infection, the most common neurotropic protozoan parasitic infection, using serological and molecular techniques. One hundred and fifteen patients with confirmed PD and 115 healthy subjects in the same age and sex distribution were enrolled in this study. Blood samples were taken from each participant and the sera was screened for anti-Toxoplasma antibodies (IgG and IgM). PCR assay was performed in duplicate using the primer pair targeting the B1 gene of Toxoplasma. Amplicons were directly sequenced to conduct the phylogenetic analysis. The prevalence of Toxoplasma infection based on IgG titer was 53% in case and 55.6% in the control groups, revealing no statistically significant association between Toxoplasma seropositivity and PD (OR = 0.90; 95% CI = 0.54-1.51; P = 0.691). According to PCR assay, the prevalence of Toxoplasma infections was 19.3% in the case and 10.4% in control groups which the difference was statistically significant (OR = 3.02; 95% CI = 1.46-6.27; P = 0.002). Multiple sequence alignment of Toxoplasma gondii isolates manifested a common haplotype by the identity: 93.6-100% and divergence: 0-6.7%. We concluded that T. gondii infection not only could not be a risk factor to PD, but even it could be concluded that patients with PD are in more risk to acquisition of infection. These results provide fresh insights into the ambiguous association between T. gondii infection and PD.

Tagged: Dopamine, metaanalysis, parkinson's disease, prevalence, Schizophrenia, sero-molecular assessment, toxoplasma gondii infection

Mental health

Latent Toxoplasma gondii infection leads to deficits in goal-directed behavior in healthy elderly

October 10, 2014
Beste, C., Getzmann, S., Gajewski, P. D., Golka, K., Falkenstein, M
Neurobiology of Aging 2014; 35: 1037-1044.

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The parasite Toxoplasma gondii has been found to manipulate the behavior of its secondary hosts to increase its own dissemination which is commonly believed to be to the detriment of the host (manipulation hypothesis). The manipulation correlates with an up-regulation of dopaminergic neurotransmission. In humans, different pathologies have been associated with T. gondii infections but most latently infected humans do not seem to display overt impairments. Since a dopamine plus does not necessarily bear exclusively negative consequences in humans, we investigated potential positive consequences of latent toxoplasmosis (and the presumed boosting of dopaminergic neurotransmission) on human cognition and behavior. For this purpose, we focused on action cascading which has been shown to be modulated by dopamine. Based on behavioral and neurophysiological (EEG) data obtained by means of a stop-change paradigm, we were able to demonstrate that healthy young humans can actually benefit from latent T. gondii infection as regards their performance in this task (as indicated by faster response times and a smaller P3 component). The data shows that a latent infection which is assumed to affect the dopaminergic system can lead to paradoxical improvements of cognitive control processes in humans.

Tagged: action cascading, animal behavior, attention, basal ganglia, cognitive flexibility, Dopamine, eeg, error, event-related potentials, executive function, executive functions, Human, latent toxoplasmosis, manipulation hypothesis, modulation, Parasite, parkinson's disease, stop-change paradigm, toxoplama gondii

Mental health

Latent Toxoplasma gondii infection leads to improved action control

October 10, 2014
Stock, A. K., von Heinegg, E. H., Kohling, H. L., Beste, C.
Brain Behavior and Immunity 2014; 37: 103-108

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Cognitive functions Mental health Motor functions

Toxoplasmosis and neuropsychiatric diseases: can serological studies establish a clear relationship?

October 11, 2013
Fabiani, S., Pinto, B., Bruschi, F.
Neurological Sciences 2013; 34: 417-425

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Toxoplasmosis is a widespread infection, with clinical spectrum ranging from a completely asymptomatic infection to multi-organ involvement. After entering the body, the parasite forms tissue cysts and establishes a chronic infection, involving also the central nervous system (CNS). During the last years, a lot of research has focused on the possible link between exposure to T. gondii and development of neuropsychiatric disorders such as schizophrenia and Parkinson's disease (PD). If a firm association between Toxoplasma infection and neuropsychiatric disorders will be established, this would lead to novel strategies for their prevention and treatment. We will review data from serological and neurodevelopment studies relating infection with T. gondii to such neuropsychiatric diseases.

Tagged: acquired-immunodeficiency-syndrome, brain, Cerebral toxoplasmosis, frontal-cortex, gondii infection, movement-disorders, parkinson's disease, parkinsonian symptoms, prenatal infection, Risk factor, Schizophrenia, schizophrenia spectrum disorders, serological studies, Toxoplasma gondii

Mental health

Latent toxoplasmosis and human

January 10, 2012
Dalimi, A., Abdoli, A.
Iranian Journal of Parasitology 2012; 7: 1-17

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Toxoplasmosis is one of the most common parasitic diseases worldwide. Although estimated that one third of the world's population are infected with Toxoplasma gondii, but the most common form of the disease is latent (asymptomatic). On the other hand, recent findings indicated that latent toxoplasmosis is not only unsafe for human, but also may play various roles in the etiology of different mental disorders. This paper reviews new findings about importance of latent toxoplasmosis (except in immunocompromised patients) in alterations of behavioral parameters and also its role in the etiology of schizophrenia and depressive disorders, obsessive compulsive disorder, Alzheimer's diseases and Parkinson's disease, epilepsy, headache and or migraine, mental retardation and intelligence quotients, suicide attempt, risk of traffic accidents, sex ratio and some possible mechanisms of T gondii that could contribute in the etiology of these alterations.

Tagged: 1st-episode schizophrenia, alzheimers-disease, behavioral parameter, congenital toxoplasmosis, cryptogenic epilepsy, gondii infection, kynurenic acid, mental disorder, parasite toxoplasma, parkinson's disease, serum interleukin-6, taxoplasma gondii, toxoplasmosis, traffic accidents

Behavior Cognitive functions Mental health Reviews

Could Toxoplasma gondii have any role in Alzheimer disease?

October 19, 2011
Kusbeci, O. Y., Miman, O., Yaman, M., Aktepe, O. C., Yazar, S.
Alzheimer Disease and Associated Disorders 2011; 25: 1-3

Tagged: activated microglia, alzheimer disease, antibodies, brain, infection, inflammation, interferon-gamma, mechanism, neurodegeneration, neuroinflammation, parkinson's disease, pathogenesis, Schizophrenia, Toxoplasma gondii, toxoplasmosis

Mental health

The probable relation between Toxoplasma gondii and Parkinson’s disease

October 19, 2010
Miman, O., Kusbeci, O. Y., Aktepe, O. C., Cetinkaya, Z.
Neuroscience Letters 2010; 475: 129-131

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Parkinson's disease (PD), a chronic progressive neurodegenerative disorder, has a mainly unknown multifactorial etiology. Neuroinflammatory mechanisms might contribute to the cascade of events leading to neuronal degeneration. Toxoplasmosis can be associated with various neuropsychiatric disorders. The most commonly affected central nervous system (CNS) region in toxoplasmosis is the cerebral hemisphere, followed by the basal ganglia, cerebellum and brain stem. Therefore, in this study, we aimed to investigate the possible association between Toxoplasma infection and PD by evaluating the serum anti-Toxoplasma gondii IgG antibodies. There were no difference between the socioeconomic status of the patients and control subjects and magnetic resonance images of the patients were normal. Serum anti-T. gondii IgG levels were measured using ELISA. There was no statistically significant differences among the patients and control subjects with respect to age (66.01 +/- 12.14 years, 62.42 +/- 5.93 years, p = 0.089; respectively) and gender. The sero-positivity rate for anti-T. gondii IgG antibodies in PD patients and control groups were 42.3 and 22.5%, respectively, and they were statistically significant (p = 0.006). These results suggest that Toxoplasma infection may be involved in the pathogenetic mechanisms of PD. If confirmed, this hypothesis would represent a valuable advancement in care of patients with Parkinson's disease. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

Tagged: antibodies, brain, cryptogenic epilepsy, encephalitis, host, infection, metaanalysis, mice, neurodegeneration, neuroinflammation, neurons, parkinson's disease, Schizophrenia, Toxoplasma gondii, toxoplasmosis

Mental health

Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

parkinson’s disease