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Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

metabolic syndrome

Latent Toxoplasma gondii infection is associated with decreased serum triglyceride to high-density lipoprotein cholesterol ratio in male patients with schizophrenia

May 3, 2018
Sagud, M. Vlatkovic, S. Strac, D.S. Sviben, M. Zivkovic, M. Vilibic, M. Vuksan-Cusa, B. Mihaljevic-Peles, A. Pivac, N.
Compr. Psychiat. 2018; 82: 115-120
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Previous studies suggested a complex association between Toxoplasma gondii (TG) infection and host lipid metabolism Both TG infection and metabolic disturbances are very common in patients with schizophrenia, but this relationship is not clear. Methods: In this cross-sectional study, we evaluated the association between TG seropositivity, serum lipid levels, body mass index (BMI) and metabolic syndrome (MetS) in 210 male inpatients with schizophrenia. Results: In our sample of schizophrenia patients, with the mean age of 43.90 +/- 12.70 years, the rate of TG seropositivity was 52.38% and the prevalence of MetS was 17%. Patients with the TG antibodies had lower serum triglyceride levels and body weight compared to TG seronegative patients, despite having more frequently received antipsychotics (clozapine, olanzapine risperidone and quetiapine), which are well known to induce weight gain and metabolic abnormalities. However, the only significant change in metabolic parameters, observed in TG seropositive patients with schizophrenia, was decreased serum triglyceride to high-density lipoprotein cholesterol (HDL-C) ratio. No associations were observed between TG seropositivity and serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and glucose levels, waist circumference, BMI and the rate of MetS. Conclusion: This is the first report of the association between TG infection and decreased serum triglyceride to HDL-C ratio in a sample of carefully selected men with chronic schizophrenia.

Tagged: body mass index, metabolic syndrome, schizophrenia patients, serum lipid indices, toxoplasma gondii infection

Mental health

Immunity, inflammation, and bipolar disorder: Diagnostic and therapeutic implications

October 11, 2013 141 Comments
Hamdani, N., Doukhan, R., Kurtlucan, O., Tamouza, R., Leboyer, M.
Current Psychiatry Reports 2013; 15
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Bipolar disorder is now known to be associated not only with highly prevalent co-occurring psychiatric and substance use disorders but also with medical comorbidities, such as cardiovascular diseases, diabetes mellitus, obesity and thyroid dysfunction. Inflammatory disturbances repeatedly observed in bipolar disorder, can explain some of the comorbidity between bipolar disorder and medical disorder. This revised perspective of bipolar disorders should promote the development of therapeutic tools. Immuno-inflammatory dysfunction may well represent a significant component of the underlying pathophysiology of the disorder. We therefore propose to review the immuno-inflammatory hypothesis in bipolar disorder considering the co-occurence with autoimmune diseases, immunological and inflammatory markers, as well as immuno-genetic markers which could lead to personalized treatments.

Tagged: auto-antibody, autoimmune diseases, bipolar disorder, borna-disease virus, c-reactive protein, cardiovascular risk-factors, cell-mediated-immunity, crp, cytokines, depressive patients, endogenous retroviruses comorbid substance use disorder, immuno-genetic, lithium treatment, medical comorbidity, metabolic syndrome, mood disorders, psychiatry, Toxoplasma gondii

Mental health

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