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Toxoplasma gondii & Human Phenotype

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From toxoplasmosis to schizophrenia via nMda dysfunction: peptide overlap between Toxoplasma gondii and N-Methyl-D-aspartate receptors as a potential Mechanistic Link.

October 2, 2017 Leave a Comment
Lucchese, G.
Frontiers in Psychiatry 2017; 8
Click for abstract
The present work aims at investigating how Toxoplasma gondii (T. gondii) infection may be linked to N-methyl-D-aspartate receptor (NMDAR) dysfunction in schizophrenia and related disorders and puts forward the hypothesis that immune responses against T. gondii may involve NMDARs. Indeed, the analysis of the protozoan proteome and NMDAR subunits for peptide commonalities shows a massive peptide overlap and supports the possibility that anti-T. gondii immune responses raised during active protozoan infection may cross-react with host NMDARs, determining disruption of neural circuits and cognitive deficits. In particular, the NMDA 2D subunit, which is mainly expressed in parvalbumin-positive interneurons, appears to be a hotspot for potential T. gondii-induced cross-reactive immune attacks.

Tagged: bipolar disorder, brain activity rat-brain antibodies, gamma oscillations, glun2d subunit, glutamate-receptor, hippocampal interneurons, immune crossreactivity, ketamine, n-methyl-d-aspartate receptors, neural oscillations, nmda 2d, parvalbumin-positive interneurons, peptide commonality, Schizophrenia, Toxoplasma gondii

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