• About
  • Keywords

Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

influenza hemagglutinin peptide

Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: Cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii.

October 30, 2006
Carter CJ.
Schizophrenia Bulletin 2006; 35: 1163-1182
Click for abstract
Over 130 genes have been associated with schizophrenia in genetic studies. None of these has reached a sufficient level of confidence to be accepted as a universal susceptibility gene and problems of replicability suggest that many may be false positives. Nevertheless, these genes can be grouped into distinct families related to glutamate transmission (in particular related to NMDA receptor function), the control of synaptic plasticity, dopaminergic transmission, oxidative stress, glutathione and quinone metabolism and oligodendrocyte viability. These families mirror the processes disrupted in the schizophrenic brain and certain gene families can be linked together to form a clearly defined signalling cascade involved in the phenomenon of NMDA receptor-dependent long-term potentiation and synaptic plasticity, that may be interconnected with oligodendrocyte and oxidative stress-related pathways. Many of the protein products of these genes interact with each other, forming complex integrated networks. Certain high-interest genes (for example DISC1, NRG1, COMT) may exert multiple effects on different areas of these pathways, while others exert more specific effects on certain branches. The convergence of a large number of genes on a definable signaling network raises the possibility of numerous interactions between gene candidates, and suggests that a targeted multigenic pathway approach would be useful in gene association studies. (c) 2006 Elsevier B.V. All rights reserved.

Tagged: association, catechol-o-methyltransferase, cell-death, cortical pyramidal neurons, dendritic spine density, DNA microarray, Dopamine, gene, glutathione, influenza hemagglutinin peptide, multigenic, nitric-oxide synthase, nmda, nmda receptor, oligodendrocyte, oxidative stress, polymorphism, prefrontal cortex, quinone, Schizophrenia, synaptic plasticity

Mental health

Topics

  • Behavior 105
  • Cognitive functions 64
  • Mental health 439
  • Morphology 6
  • Motor functions 10
  • Personality 36
  • Physical health 134
  • Reproduction 36
  • Reviews 40
  • Sensory functions 3
  • Uncategorized 2

Archives

Recent articles

  • Mortality Patterns of Toxoplasmosis and Its Comorbidities in Tanzania: A 10-Year Retrospective Hospital-Based Survey February 6, 2020
  • The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia–the risk factor or an indication of a contact with cat? February 6, 2020
  • The Association between Toxoplasma gondii Infection and Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis February 6, 2020

Recent Comments

  • buy nord vpn on Can sex ratios at birth be used in the assessment of public health, and in the identification of causes of selected pathologies?
  • reddit best vpn 2022 on Antibodies to Toxoplasma gondii in individuals with mania
  • best anonymous vpn on Increased pregnancy weight gain in women with latent toxoplasmosis and RhD-positivity protection against this effect
  • fontaneros san jose de la rinconada on Diagnostic problems in psychiatry with regard to acquired toxoplasmosis
  • where to buy a vpn on Toxoplasma gondii infection and common mental disorders in the Finnish general population

Meta

  • Log in
  • Entries feed
  • Comments feed
  • WordPress.org

Copyright © 2022 Toxoplasma gondii & Human Phenotype.

ToxoBehavior WordPress Theme by Jelena Braum