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Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

immunoglobulin G/analysis

Investigation of probable relationship between Toxoplasma gondii and cryptogenic epilepsy

October 30, 2003
Yazar S, et al
Seizure-European Journal of Epilepsy 2003; 12: 107-109.
Click for abstract
PURPOSE: Cryptogenic epilepsy, defines a group of epilepsy syndromes for which an aetiology is unknown but an underlying brain disease is suspected. We selected patients in this subgroup of epilepsy and investigated the sero-positivity rate for anti-Toxoplasma IgG antibodies by Enzyme Linked Immunosorbent Assay (ELISA). We investigated the probable relationship between Toxoplasma gondii and cryptogenic epilepsy. METHODS: We selected 50 patients with cryptogenic epilepsy, 50 patients with known cause epilepsy and 50 healthy volunteers and investigated the sero-positivity rate for anti-Toxoplasma IgG antibodies by ELISA. RESULTS: The sero-positivity rate for anti-Toxoplasma IgG antibodies among cryptogenic epilepsy patients (52%) was found to be higher than healthy volunteers (18%) and known cause epilepsy patients (22%) with statistical significance, (X(2)=18.095, P<0.01). CONCLUSION: There might be a causal relationship between chronic toxoplasmosis and the aetiology of cryptogenic epilepsy

Tagged: animals, antibodies, cerebral/*parasitology, chronic disease, enzyme-linked immunosorbent assay, epilepsy/blood/*parasitology, humans, immunoglobulin G/analysis, protozoan/analysis, Toxoplasma/immunology/isolation & purification, toxoplasmosis

Physical health

Landau-Kleffner syndrome–epileptic aphasia in children–possible role of Toxoplasma gondii infection

November 8, 1988
Michaoowicz, R., Jozwiak, S., Ignatowicz, R., Szwabowska-Orzeszko, E.
Acta Paediatrica Hungarica 1988; 29: 337-342
Click for abstract
The association of unusual types of aphasia and epilepsy (Landau-Kleffner syndrome) has been described in three children. The children were 5 to 11 years of age and all have EEG abnormalities. Speech disorders appeared after epileptic seizures. No organic causes of the disease have been found in axial computed tomography. In all described cases the increased titer of IgG antibodies against Toxoplasma gondii has been observed. The authors suggest that the Toxoplasma gondii infection should be taken into account as a possible cause of Landau-Kleffner syndrome.

Tagged: antibodies, aphasia/*etiology, child, electroencephalography, epilepsy/*etiology, female, humans, immunoglobulin G/analysis, male, preschool, protozoan/analysis, syndrome, toxoplasmosis/*complications/immunology

Physical health

Topics

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  • Cognitive functions 64
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  • Physical health 134
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  • Reviews 40
  • Sensory functions 3
  • Uncategorized 2

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