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Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

host-parasite interaction

Neurophysiological changes induced by chronic Toxoplasma gondii infection

December 8, 2017
Tedford, E., McConkey, G.
Pathogens 2017; 6: Artn 19 10.3390/Pathogens6020019
Click for abstract
Although the parasite Toxoplasma gondii is one of the most pervasive neurotropic pathogens in the world, the host-parasite interactions during CNS infection and the consequences of neurological infection are just beginning to be unraveled. The chronic stages of infection have been considered dormant, although several studies have found correlations of infection with an array of host behavioral changes. These may facilitate parasite transmission and impact neurological diseases. During infection, in addition to the presence of the parasites within neurons, host-mediated neuroimmune and hormonal responses to infection are also present. T. gondii induces numerous changes to host neurons during infection and globally alters host neurological signaling pathways, as discussed in this review. Understanding the neurophysiological changes in the host brain is imperative to understanding the parasitic mechanisms and to delineate the effects of this single-celled parasite on health and its contribution to neurological disease

Tagged: alzheimers-disease, bipolar disorder, central-nervous-system, gene-expression, host-parasite interaction, immune system, infection, Neurophysiology, Toxoplasma gondii

BehaviorMental health

Neurophysiological changes induced by chronic Toxoplasma gondii Infection.

March 13, 2017
Tedford, E., McConkey, G.
Pathogens. 2017; 6: 19-31
Click for abstract
Although the parasite Toxoplasma gondii is one of the most pervasive neurotropic pathogens in the world, the host-parasite interactions during CNS infection and the consequences of neurological infection are just beginning to be unraveled. The chronic stages of infection have been considered dormant, although several studies have found correlations of infection with an array of host behavioral changes. These may facilitate parasite transmission and impact neurological diseases. During infection, in addition to the presence of the parasites within neurons, host-mediated neuroimmune and hormonal responses to infection are also present. T. gondii induces numerous changes to host neurons during infection and globally alters host neurological signaling pathways, as discussed in this review. Understanding the neurophysiological changes in the host brain is imperative to understanding the parasitic mechanisms and to delineate the effects of this single-celled parasite on health and its contribution to neurological disease.

Tagged: alzheimers-disease, bipolar disorder, catecholamine, central-nervous-system, dendritic cells, dependent manner, DNA, Dopamine, gamma-interferon, gene-expression, glutamatergic, host-parasite interaction, immune system, infection, methylation, neuroimmune, Neurophysiology, parasitic, testosterone, Toxoplasma gondii

Mental health

Topics

  • Behavior 105
  • Cognitive functions 64
  • Mental health 439
  • Morphology 6
  • Motor functions 10
  • Personality 36
  • Physical health 134
  • Reproduction 36
  • Reviews 40
  • Sensory functions 3
  • Uncategorized 2

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Recent articles

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