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Psychiatric disorders in Toxoplasma seropositive patients – CD8 connection

October 11, 2013 11 Comments
Bhadra, R., Cobb, D. A., Weiss, L. M., Khan, I. A.
Schizophrenia Bulletin 2013; 39: 485-489
Click for abstract
Although the highest numbers of studies linking an infectious agent with schizophrenia has involved the parasite Toxoplasma gondii, the mechanistic underpinnings of this correlation has remained unaddressed. Incidentally, CD8 T cells, which play a pivotal role in mediating long-term immunity to Toxoplasma, are downregulated in schizophrenia patients. Recent studies have demonstrated that CD8 response is also impaired during chronic toxoplasmosis in murine models. In light of these new findings, in this article, we discuss the potential role of CD8 T cells in causing altered mental status in Toxoplasma seropositive schizophrenia patients.

Tagged: behavior, cd8 t cells, cells, disease, Dopamine, exhaustion, gondii, infection, lymphocytes, oxoplasma, pd-1, receptors, risk factors, Schizophrenia

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