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Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

environmental risk-factors

Relationship of Toxoplasma Gondii Exposure with Multiple Sclerosis

January 4, 2016
Oruc, S.
European Journal of General Medicine, 2016, 13: 58-63
Click for abstract
Objective: Toxoplasma gondii infection is a very common parasitic disease in human. In Turkey, the rate of seropositivity was reported as 23.1% to 36%. Because of the high affinity of parasite into Central Nervous System (CNS), chronic toxoplasma infection has been found correlated with many neuropsychiatric disorders, including altered mental status, obsessive-compulsive disorder, cognitive impairment, epilepsy, headache and schizophrenia. In this study, we aimed to investigate whether T. gondii has any role in Multiple Sclerosis (MS) by measuring anti-T. gondii IgG antibodies. Methods: Fifty-two MS patients followed up and 45 controls with similar age and socioeconomic status were included in the study. Anti-T. gondii IgL antibodies of the patients and controls were studied in blood with micro-enzyme-linked immunosorbent assay (ELISA) technique. Results: Of 52 MS patients included in the study, 37 had RRMS, 10 PPMS and 5 SPMS. Mean age of onset of the disease was 31.7 +/- 10.4 (min; 14 and max; 53). Twenty three of 52 (44.2%) cases with MS and 11 of 45 (24.4%) healthy controls were positive for anti-T. gondii IgG antibodies. There was a statistically significant difference between the rates of positivity between the MS patient group and control group (p=0.042). Conclusion: This study shows a relation of chronic T. Gondii infection with MS. According to this study, experienced T. gondii infection may be one of the several environmental risk factors for MS.

Tagged: activated microglia, autoimmunity, brain, chronic infection, disease, environmental risk-factors, hygiene hypothesis, infection, inflammation, interferon-gamma, metaanalysis, multiple sclerosis, pathogenesis, Toxoplasma gondii

Physical health

Toxoplasma gondii seropositivity is negatively associated with multiple sclerosis

October 6, 2015 Leave a Comment
Stascheit, F., Paul, F., Harms, L., Rosche, B.
Journal of Neuroimmunology 2015; 285: 119-124
Click for abstract
Background: Toxoplasma (T.) gondii is a ubiquitous intracellular parasitic protozoan that was recently associated with various autoimmune diseases. Objectives: We aimed to investigate the prevalence of T. gondii IgG and IgM antibodies between MS patients and healthy controls. Methods: Sera from 163 MS, 91 clinically isolated syndrome cases and 178 age and gender matched controls were evaluated for the prevalence of T. gondii IgG antibodies utilizing chemiluminescent immunoassay (ARCHITECT). Results: MS-patients showed a significantly lower prevalence for T. gondii IgG antibodies compared to controls (333% vs. 47.9%; p = 0.011, OR = 1.8 (95% CI 12-3.2)). Conclusion: The results demonstrate a negative association between an infection with the parasite T. gondii and the presence of MS.

Tagged: antibodies, case-control studies, cigarette-smoking, environmental risk-factors, hygiene hypothesis, infection, multiple sclerosis, parasitic infections, Toxoplasma gondii

Physical health

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