elisa – Toxoplasma gondii & Human Phenotype

The relation of secondary sex ratio and miscarriage history with Toxoplasma gondii infection

August 31, 2018
Shojaee, S.,Teimouri, A., Keshavarz, H., Azami, S. J., Nouri, S.
Bmc Infectious Diseases 2018; 18: 307

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Toxoplasma gondii exposure and the risk of attention deficit hyperactivity disorder in children and adolescents

February 12, 2018
Khademvatan, S. , Riahi,F., Izadi-Mazidi,M. , Khajeddin, N., Yousefi, E.
Pediatric Infectious Disease Journal 2018; 37: 1097-1100

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Seroepidemiological study of Toxoplasma gondii infection among psychiatric patients in Mashhad, Northeast of Iran

October 3, 2017
Abdollahian, E., Shafiei, R., Mokhber, N., Kalantar, K., Fata, A.
Iranian Journal of Parasitology 2017; 12: 117-122

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Possible link between Toxoplasma gondii infection and mood disorders in Lorestan Province, Western Iran

October 6, 2016
Kheirandish, F., Nazari, H., Mahmoudvand, H., Yaseri, Y., Tarahi, M. J., Fallahi, S., Ezatpour, B.
Archives of Clinical Infectious Diseases 2016; 11.

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Background: A large number of epidemiological evidence in humans and experimental studies in rodents have hypothesized that Toxoplasma gondii is a potentially relevant etiological factor in some mood disorders. Objectives: The aim of this study was to investigate whether latent toxoplasmosis has any role in mood disorders such as schizophrenia and bipolar disease in Western Iran. Patients and Methods: A total of 170 patients including 85 schizophrenia and 85 bipolar patients referred to the only psychiatric hospital in Lorestan province in Khorramabd city, Western Iran, and 170 healthy volunteers were screened for IgG and IgM anti-T. gondii antibodies by the Enzyme Linked Immunosorbent Assay (ELISA). Structured questionnaires were used to obtain information on risk factors for T. gondii infection. Results: Out of the 170 psychiatric patients, 103 (63.5%) patients were seropositive for IgG antibody and 14 (8.2%) were seropositive for IgM antibody. Of the 85 bipolar patients, 54 (63.5%) and 6 (7%) were found positive for anti-T. gondii IgG and IgM antibodies, respectively; whereas among 85 schizophrenia patients, 49 (57.6%) and 8 (9.4%) samples were found positive for anti-T. gondii IgG and IgM antibodies, respectively. From 170 healthy volunteers, 73 (42.9%) tested seropositive for anti-T. gondii antibodies; 65 (38.2%) tested seropositive for IgG antibody and 8 (4.7%) tested seropositive for IgM antibody. There was a significant difference in T. gondii IgG positivity between the psychiatric patients and control groups (P = 0.009). Several risk factors, which were significantly related to T. gondii seropositivity in psychiatric patients are being in contact with cats (P = 0.004), eating unwashed raw vegetables (P < 0.001), raw-milk/egg consumption (P = 0.001), and drinking clean water (P = 0.035). Conclusions: We concluded that psychiatric patients in general and schizophrenia and bipolar cases in particular had a significantly higher relative frequency of T. gondii infection than healthy individuals of Lorestan Province, Western Iran.

Toxoplasmosis and Alzheimer: can Toxoplasma gondii really be introduced as a risk factor in etiology of Alzheimer?

October 6, 2016
Mahami-Oskouei, M., Hamidi, F., Talebi, M., Farhoudi, M., Taheraghdam, A. A., Kazemi, T., Sadeghi-Bazargani, H., Fallah, E.
Parasitology Research 2016; 115: 3169-3174.

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Effect of toxoplasmosis on personality profiles of Iranian men and women

October 11, 2013
Khademvatan, S., Khajeddin, N., Saki, J., Izadi-Mazidi, S.
South African Journal of Science 2013; 109: 92-95

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Seroepidemiology of Toxoplasma gondii infection in drivers involved in road traffic accidents in the metropolitan area of Guadalajara, Jalisco, Mexico

October 10, 2013
Galvan-Ramirez, M. D., Sanchez-Orozco, L. V., Rodriguez, L. R., Rodriguez, S., Roig-Melo, E., Sanroman, R. T., Chiquete, E., Armendariz-Borunda, J.
In: Parasites & Vectors 2013;6:10.1186/1756-3305-6-294

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Background: The prevalence of toxoplasmosis in the general population of Guadalajara, Mexico, is around 32%. Toxoplasmosis can cause ocular lesions and slowing of reaction reflexes. Latent toxoplasmosis has been related with traffic accidents. We aimed to assess the prevalence of anti-Toxoplasma gondii antibodies and visual impairments related with traffic accidents in drivers from the metropolitan Guadalajara. Methods: We prospectively evaluated the prevalence of IgG and IgM anti-T. gondii antibodies in 159 individuals involved in traffic accidents, and in 164 control drivers never involved in accidents. Cases of toxoplasmosis reactivation or acute infection were detected by PCR in a subset of 71 drivers studied for the presence of T. gondii DNA in blood samples. Ophthalmologic examinations were performed in drivers with IgG anti-T. gondii antibodies in search of ocular toxoplasmosis. Results: Fifty-four (34%) traffic accident drivers and 59 (36%) controls were positive to IgG anti-T. gondii antibodies (p = 0.70). Among the 113 seropositive participants, mean anti-T. gondii IgG antibodies titers were higher in traffic accident drivers than in controls (237.9 +/- 308.5 IU/ml vs. 122.9 +/- 112.7 IU/ml, respectively; p = 0.01 by Student's t test, p = 0.037 by Mann-Whitney U test). In multivariate analyses, anti-T. gondii IgG antibody titers were consistently associated with an increased risk of traffic accidents, whereas age showed an inverse association. The presence of IgM-anti-T. gondii antibodies was found in three (1.9%) subjects among traffic accident drives, and in two (1.2%) controls. Three (4.2%) samples were positive for the presence of T. gondii DNA, all among seropositive individuals. No signs of ocular toxoplasmosis were found in the entire cohort. Moreover, no other ocular conditions were found to be associated with the risk of traffic accidents in a multivariate analysis. Conclusions: Anti-T. gondii antibody titers are associated with the risk of traffic accidents. We could not determine any association of ocular toxoplasmosis with traffic accidents. Our results warrant further analyses in order to clarify the link between toxoplasmosis and traffic accidents

Parasitic infections and pregnancy complications

October 29, 2011
Pavlinova, J., Kincekova, J., Ostro, A., Saksun, L., Vasilkova, Z., Konigova, A.
Helminthologia 2011; 48: 8-12

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Toxoplasma infection in schizophrenia patients: A comparative study with control group

October 19, 2011
Alipour, A., Shojaee, S., Mohebali, M., Tehranidoost, M., Masoleh, F. A., Keshavarz, H.
Iranian Journal of Parasitology 2011; 6: 31-37

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Is there any role of Toxoplasma gondii in the etiology of obsessive-compulsive disorder?

October 19, 2010
Miman, O., Mutlu, E. A., Ozcan, O., Atambay, M., Karlidag, R., Unal, S.
Psychiatry Research 2010; 177: 263-265

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May Toxoplasma gondii increase suicide attempt – preliminary results in Turkish subjects?

October 19, 2010
Yagmur, F., Yazar, S., Temel, H. O., Cavusoglu, M.
Forensic Science International 2010; 199: 15-17

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Is Toxoplasma gondii a causal agent in migraine?

October 26, 2009
Koseoglu E, Yazar S, Koc I.
American Journal of the Medical Sciences 2009; 338: 120-122.

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Anti-Toxoplasma gondii antibodies in patients with schizophrenia-preliminary findings in a Turkish sample

January 10, 2007
Cetinkaya, Z., Yazar, S., Gecici, O., Namli, M. N.
Schizophrenia Bulletin 2007;33: 789-791

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Anti-Toxoplasma gondii antibodies in haemodialysis patients with chronic renal failure

October 30, 2003
Yazar, S., Demirtas, F., Yalcin, A., Yaman, O., Tokgoz, B., Utas, C., Sahin, I.
Yonsei Medical Journal 2003; 44: 288-292

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