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Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

congenital

Lack of circulating toxoplasma gondii DNA in seropositive patients with bipolar or schizophrenia spectrum disorders

February 1, 2020
Galli, L., Del Grande, C. Rindi, L., Mangia, C., Mangano, V., Schiavi, E., Masci, I., Pinto, B., Kramer, L., Dell'Osso, L., Bruschi, F.
Psychiatry Research :2019, 173: 706 - 711
Click for abstract
Toxoplasmosis has been previously associated with an increased risk of having Schizophrenia or Bipolar disorder in several epidemiological studies. The aim of this observational, cross-sectional study was to examine the seroprevalence of Toxoplasma infection in a cohort of Italian psychiatric inpatients and to verify the presence of circulating Toxoplasma gondii DNA in the seropositive subjects. Sixty-three patients affected by bipolar or schizoaffective disorders according to DSM-5 criteria were enrolled. The presence of Toxoplasma infection was firstly examined using an indirect serological method (ELFA), and three different direct PCR-based methods were performed to detect circulating DNA in the seropositive patients. The seroprevalence of infection was 28.6%, with a significant association between higher age and the infection status. PCR, nested-PCR and Real-Time PCR revealed no positive samples for Toxoplasma gondii This result is in contrast with recent data from case-control studies that detected parasite genome in patients with different neuropsychiatric diagnosis without clinical evidence of acute toxoplasmosis. Our findings are to be interpreted with caution, because of the small sample size, the heterogeneity of enrolled patients and the observational nature of the study. Further studies are needed to better define the clinical features correlated to the seropositive status in neuropsychiatric patients.

Tagged: bipolar disorder, congenital, individuals, molecular diagnosis, nested pcr, pcr, population, risk factors, Rt-PCR, schizoaffective disorder, seroprevalence, Toxoplasma gondii, toxoplasmosis

Mental health

Fetomaternal and pediatric toxoplasmosis

December 6, 2017
Oz, H. S.
Journal of Pediatric Infectious Diseases 2017; 12: 202-208
Click for abstract
Toxoplasmosis is one of the most important causes of foodborne illnesses and inflammatory complications, as well as congenital disorders. Promiscuous Toxoplasma is transmitted by contaminated food and animal produce, water, vegetations, fruits, and sexually through semen. Toxoplasma infects nucleated cells with a unique tropism formuscles and central nervous system and amind bugging malicious effect. Pregnant women with acute or reactivated toxoplasmosis can transmit Toxoplasma via transplacental transmission to the fetus. The severity of congenital toxoplasmosis depends on the gestation period, as infection in early pregnancy causes more severe consequences. Congenital toxoplasmosis complications include miscarriage, encephalitis, neurological retardation, mental illnesses, auditory, and visual inflammatory disorders, cardiovascular abnormalities, and pains. Current therapies are inefficient for congenital and chronic toxoplasmosis or have severe side effects with life-threatening complications. There is an urgent need for effective and safe therapeutic modalities to treat complications of toxoplasmosis and effective vaccines to eliminate the infectious agent. This investigation will discuss the pathogenesis of fetomaternal, congenital, and pediatric toxoplasmosis, the currently available therapies in practice, and explore those therapeutic modalities in experimental stages for promising future trials.

Tagged: congenital, gondii infection, inflammatory-bowel-disease, mind, pediatric toxoplasmosis, pregnancy, Schizophrenia, sexual transmission, to-child transmission, toxoplasmosis

Mental healthPhysical health

Toxoplasmosis: A threat to mothers and babies, but one that is preventable

May 28, 2015
Moore, S. C.
International Journal of Childbirth Education 2015; 30: 35-38
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The purpose of this article is to review definition, epidemiology, and pathophysiology of toxoplasmosis. Congenital toxoplasmosis is the focus because of its potential adverse effects on children. Transmission to fetus and diagnosis during pregnancy are discussed. Timing of prenatal as well as post-delivery treatment are summarized. Latent effects and additional diseases thought to be associated with toxoplasmosis are reviewed. Primary prevention is emphasized such as avoiding undercooked meat and contaminated fruits/vegetables; consuming only safe drinking water; and eliminating exposure to contaminated cat litter (dried feces) or soil. Secondary and tertiary prevention are addressed.

Tagged: congenital, gondii, infection, pregnancy, prevention, Schizophrenia, Toxoplasma gondii, toxoplasmosis

Mental healthReproduction

Toxoplasmic myocarditis and pericarditis

November 9, 1969
Theologi.A, Kennedy BJ
American Journal of Medicine 1969; 47: 169-&
Tagged: atibodies/analysis, congenital, humans, myocarditis/diagnosis/*etiology/pathology, myocardium/pathology, ocular, pericarditis/*etiology, Toxoplasma/*isolation & purification, toxoplasmosis, toxoplasmosis/therapy

Physical health

Topics

  • Behavior 105
  • Cognitive functions 64
  • Mental health 439
  • Morphology 6
  • Motor functions 10
  • Personality 36
  • Physical health 134
  • Reproduction 36
  • Reviews 40
  • Sensory functions 3
  • Uncategorized 2

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Recent articles

  • Mortality Patterns of Toxoplasmosis and Its Comorbidities in Tanzania: A 10-Year Retrospective Hospital-Based Survey February 6, 2020
  • The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia–the risk factor or an indication of a contact with cat? February 6, 2020
  • The Association between Toxoplasma gondii Infection and Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis February 6, 2020

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