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Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

attempts

The association between Toxoplasma gondii infection and postpartum blues

February 4, 2020
Gao, J. M., He, Z. H., Xie, Y. T., Hide, G., Lai, D. H., Lun, Z. R.
Journal of Affective Disorder 2019, 250: 404 - 409 schizophrenia prevalence
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Introduction and Aim: Toxoplasma gondii is an intracellular protozoan parasite infecting approximately 30% of the global human population. It has often been suggested that chronic infection with T. gondii is related to personality changes and various mental disorders including depression. It is not known whether this includes post-partum blues or depression. In this study, we test the hypothesis that there is a relationship between T. gondii infection and post-partum blues by measuring the association between infection and postpartum blues. Methods: A total of 475 Chinese women who have just given birth were detected serology for Toxoplasma IgG and IgM antibodies, and evaluated the degree of depression by Hamilton Depression Scale (HAMD) score. Data were analyzed by Chi-square or Fisher's Exact tests using SPSS software. Results: We found an overall Toxoplasma seroprevalence of 5.68% (27/475; 95% CI: 3.59-7.77) which was broken down into a prevalence of 6.60% (7/106; 95% CI: 1.80-11.41) in mothers with post-partum blues and 5.42% (20/369; 95% CI: 3.10-7.74) in non-affected mothers. There was no significant association between infection and post-partum blues (p= 0.64). Conclusion: The results suggest that there is no relationship between T. gondii infection and postpartum blues, at least in this sample of patients from China

Tagged: antibody-titers, attempts, comon mental-disorders, Hamilton depression scale, Major depression, maternal depression, newborn, postpartum blues, pregnant women, puerpera, seroprevalence, social support, suicide, Toxoplasma gondii

BehaviorMental healthPersonality

Toxoplasma gondii: Biological parameters of the connection to schizophrenia

February 12, 2018
Xiao, J. C. ,Prandovszky, E. , Kannan,G., Pletnikov, M. V. Dickerson, ,F. , Severance , E. G., Yolken, R. H.
Schizophrenia Bulletin 2018; 44: 983-992
Click for abstract
It is increasingly evident that the brain is not truly an immune privileged site and that cells of the central nervous system are sensitive to the inflammation generated when the brain is fighting off infection. Among the many microorganisms that have access to the brain, the apicomplexan protozoan Toxoplasma gondii has been one of the most studied. This parasite has been associated with many neuropsychiatric disorders including schizophrenia. This article provides a comprehensive review of the status of Toxoplasma research in schizophrenia. Areas of interest include (1) the limitations and improvements of immune-based assays to detect these infections in humans, (2) recent discoveries concerning the schizophrenia-Toxoplasma association, (3) findings of Toxoplasma neuropathology in animal models related to schizophrenia pathogenesis, (4) interactions of Toxoplasma with the host genome, (5) gastrointestinal effects of Toxoplasma infections, and (6) therapeutic intervention of Toxoplasma infections.

Tagged: attempts, bipolar disorder, complement c1q, congenital toxoplasmosis, immune activation, infection, microorganism, molecular-mechanisms, murine toxoplasmosis, pathogenesis, psychiatric-disorders, risk factors, suicide, tissue cyst formation

Mental health

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Recent articles

  • Mortality Patterns of Toxoplasmosis and Its Comorbidities in Tanzania: A 10-Year Retrospective Hospital-Based Survey February 6, 2020
  • The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia–the risk factor or an indication of a contact with cat? February 6, 2020
  • The Association between Toxoplasma gondii Infection and Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis February 6, 2020

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