TCI

OBJECTIVES : Toxoplasma gondii , a parasitic protozoan, infects about 30–60% of people worldwide. Toxoplasma is known to induce behavioral changes and an increase of dopamine in mice. The presence of anti- Toxoplasma antibodies (latent toxoplasmosis) is also a risk factor for schizophrenia. Latent toxoplasmosis in men (male soldiers) is associated with lower novelty seeking. As the novelty seek - ing is supposed to negatively correlate with level of dopamine, the observed effect was interpreted as indirect evidence of increased dopamine levels in subjects with toxoplasmosis. However, it is also possible that the observed effect was caused by association of both novelty seeking and Toxoplasma infection with a third factor, e.g. size of place of residence. METHODS : Personality profile of 290 blood donors (205 men and 85 women) were measured by Cloninger’s TCI (Temperament and Character Inventory) and their blood samples were assayed for the presence of anti- Toxoplasma antibodies. Dif - ference between Toxoplasma -infected and Toxoplasma -free subjects was tested with ANCOVA method with gender, size of place of residence, and age as covari - ates. RESULTS : The present analysis revealed that lower novelty seeking was associ - ated with latent toxoplasmosis both in men and women. The effect of infection on novelty seeking remained significant even after adjustment for size of place of residence (p<0.0). CONCLUSION : Decreased novelty seeking in Toxoplasma -infected subjects have been already confirmed in three independent populations (male soldiers and male and female blood donors). These findings suggest that the local inflamma - tion-induced increase in dopamine in the brain of infected subjects can represent a missing link between toxoplasmosis and schizophrenia