• About
  • Keywords

Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

receptors

Psychiatric disorders in Toxoplasma seropositive patients – CD8 connection

October 11, 2013 11 Comments
Bhadra, R., Cobb, D. A., Weiss, L. M., Khan, I. A.
Schizophrenia Bulletin 2013; 39: 485-489
Click for abstract
Although the highest numbers of studies linking an infectious agent with schizophrenia has involved the parasite Toxoplasma gondii, the mechanistic underpinnings of this correlation has remained unaddressed. Incidentally, CD8 T cells, which play a pivotal role in mediating long-term immunity to Toxoplasma, are downregulated in schizophrenia patients. Recent studies have demonstrated that CD8 response is also impaired during chronic toxoplasmosis in murine models. In light of these new findings, in this article, we discuss the potential role of CD8 T cells in causing altered mental status in Toxoplasma seropositive schizophrenia patients.

Tagged: behavior, cd8 t cells, cells, disease, Dopamine, exhaustion, gondii, infection, lymphocytes, oxoplasma, pd-1, receptors, risk factors, Schizophrenia

Mental health

Anti-Toxoplasma gondii antibodies in patients with chronic heart failure

October 30, 2006
Yazar, S., Gur, M., Ozdogru, I., Yaman, O., Oguzhan, A., Sahin, I.
Journal of Medical Microbiology 2006; 55: 89-92
Click for abstract
Chronic heart failure (CHF) involves interactions between the cardiovascular, neuroendocrine and immune systems. This study investigated the seropositivity rate for anti-Toxoplasma IgG and IgM antibodies by ELISA in patients with CHF. Ninety-seven patients with CHF and 50 healthy volunteers were selected for this investigation. The seropositivity rate for anti-Toxoplasma IgG antibodies among CHF patients (68%) was significantly higher than in healthy volunteers (36%). Thus, parasitological screening of this group of patients should be periodically performed to prevent the possible dissemination of toxoplasmosis.

Tagged: cytokines, immunity, infections, mechanisms, natural-killer-cells, receptors, resistance

Physical health

Topics

  • Behavior 105
  • Cognitive functions 64
  • Mental health 439
  • Morphology 6
  • Motor functions 10
  • Personality 36
  • Physical health 134
  • Reproduction 36
  • Reviews 40
  • Sensory functions 3
  • Uncategorized 2

Archives

Recent articles

  • Mortality Patterns of Toxoplasmosis and Its Comorbidities in Tanzania: A 10-Year Retrospective Hospital-Based Survey February 6, 2020
  • The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia–the risk factor or an indication of a contact with cat? February 6, 2020
  • The Association between Toxoplasma gondii Infection and Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis February 6, 2020

Recent Comments

  • Food on Diagnostic problems in psychiatry with regard to acquired toxoplasmosis
  • Ukraine-Russia on Neonatal antibodies to infectious agents and risk of bipolar disorder: a population-based case-control study
  • Ukraine-Russia on Loss of psychic auto-activation. Obsessive-compulsive behavior. Toxoplasmic abscess of the basal ganglia
  • Ukraine-Russia on Toxoplasma gondii infection and common mental disorders in the Finnish general population
  • Ukraine-Russia on Herpesviruses and Toxoplasma gondii in orbital frontal cortex of psychiatric patients

Meta

  • Log in
  • Entries feed
  • Comments feed
  • WordPress.org

Copyright © 2022 Toxoplasma gondii & Human Phenotype.

ToxoBehavior WordPress Theme by Jelena Braum