• About
  • Keywords

Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

plasticity

Is there any role of Toxoplasma gondii in the etiology of obsessive-compulsive disorder?

October 19, 2010
Miman, O., Mutlu, E. A., Ozcan, O., Atambay, M., Karlidag, R., Unal, S.
Psychiatry Research 2010; 177: 263-265
Click for abstract
Obsessive-compulsive disorder (OCD) is a common psychiatric illness. Although the aetiology of OCD is still unknown, the family-genetic data show that familial forms of OCD may be associated with a specific genetic susceptibility. Recent investigations have associated development of OCD with infectious illness. Toxoplasmic encephalitis (TE) is a common presentation of Toxoplasma gondii infection of the central nervous system (CNS). The most commonly affected CNS region in TE is the cerebral hemisphere, followed by the basal ganglia, cerebellum and brain stem. The basal ganglia has been implicated in the development of OCD. Therefore, in this study, it was aimed to investigate a possible association between Toxoplasma infection and OCD. We selected 42 patients with OCD and 100 healthy volunteers, and investigated the sero-positivity rate for anti-Toxoplasma IgG antibodies by Enzyme Linked Immunosorbent Assay (ELISA). The sero-positivity rate for anti-T. gondii IgG antibodies among OCD patients (47.62%) was found to be significantly higher than the rate in healthy volunteers (19%). This is the first report to examine a potential association between Toxoplasma infection and OCD. The main finding of the present study is an increased level of IgG antibodies to T. gondii in OCD patients when compared with the level in healthy controls. There might be a causal relationship between chronic toxoplasmosis and the aetiology of OCD. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

Tagged: basal ganglia, brain, children, disease, elisa, infection, obsessive-compulsive disorder (ocd), plasticity, Toxoplasma gondii

Mental health

Topics

  • Behavior 105
  • Cognitive functions 64
  • Mental health 439
  • Morphology 6
  • Motor functions 10
  • Personality 36
  • Physical health 134
  • Reproduction 36
  • Reviews 40
  • Sensory functions 3
  • Uncategorized 2

Archives

Recent articles

  • Mortality Patterns of Toxoplasmosis and Its Comorbidities in Tanzania: A 10-Year Retrospective Hospital-Based Survey February 6, 2020
  • The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia–the risk factor or an indication of a contact with cat? February 6, 2020
  • The Association between Toxoplasma gondii Infection and Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis February 6, 2020

Recent Comments

  • https://franciscozfko39629.bloggazza.com/15899817/voj8-the-best-free-online-casino-slot-machine-in-brazil on Diagnostic problems in psychiatry with regard to acquired toxoplasmosis
  • stromectol online on Selected infectious agents and risk of schizophrenia among U.S. military personnel
  • https://reidjouy73962.blogacep.com/17661827/voj8-the-best-free-online-casino-slot-machine-in-brazil on Diagnostic problems in psychiatry with regard to acquired toxoplasmosis
  • madridbet on Rats, cats, people and parasites: the impact of latent toxoplasmosis on behaviour
  • https://johnnyqwbf07396.actoblog.com/17306169/voj8-the-best-free-online-casino-slot-machine-in-brazil on Diagnostic problems in psychiatry with regard to acquired toxoplasmosis

Meta

  • Log in
  • Entries feed
  • Comments feed
  • WordPress.org

Copyright © 2023 Toxoplasma gondii & Human Phenotype.

ToxoBehavior WordPress Theme by Jelena Braum