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Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

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Toxoplasma gondii infection, from predation to schizophrenia: can animal behaviour help us understand human behaviour?

January 4, 2013
Webster, J. P., Kaushik, M., Bristow, G. C., McConkey, G. A.
Journal of Experimental Biology 2013; 216: 99-112
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We examine the role of the protozoan Toxoplasma gondii as a manipulatory parasite and question what role study of infections in its natural intermediate rodent hosts and other secondary hosts, including humans, may elucidate in terms of the epidemiology, evolution and clinical applications of infection. In particular, we focus on the potential association between T. gondii and schizophrenia. We introduce the novel term 'T. gondii-rat manipulation-schizophrenia model' and propose how future behavioural research on this model should be performed from a biological, clinical and ethically appropriate perspective.

Tagged: 3rs, altered behavior, behaviour, by-product, card sorting test, dopamine hypothesis, elevated plus-maze, intermediate host, male norway rats, manipulation., mouse, nmda receptor hypofunction, obsessive-compulsive disorder, pathology, rat, rattus-norvegicus, recognition memory, schistosoma-mansoni, Schizophrenia, secondary host, Toxoplasma gondii

BehaviorMental healthReviews

Rats, cats, people and parasites: the impact of latent toxoplasmosis on behaviour

November 7, 2001
Webster, J. P.
Microbes and Infection 2001; 3: 1037-1045
Click for abstract
The manipulation hypothesis states a parasite may alter host behaviour for its own benefit, often by enhancing its transmission rate through the food chain. This paper reviews studies on the potential impact of one parasite, Toxoplasma gondii, on host behaviour, both on rodents, where altered responses may be proposed to benefit the parasite, and humans, where altered responses may arise as a side-effect of infection with no current adaptive significance. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

Tagged: behaviour, congenital toxoplasmosis, gondii, infections, manipulation., mice, mouse, Parasite, personality, prevalence, rattus-norvegicus, toxoplasmosis, transmission, wild brown-rats

BehaviorMental health

Topics

  • Behavior 105
  • Cognitive functions 64
  • Mental health 439
  • Morphology 6
  • Motor functions 10
  • Personality 36
  • Physical health 134
  • Reproduction 36
  • Reviews 40
  • Sensory functions 3
  • Uncategorized 2

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Recent articles

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  • The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia–the risk factor or an indication of a contact with cat? February 6, 2020
  • The Association between Toxoplasma gondii Infection and Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis February 6, 2020

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