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Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

minnesota

Cryptogenic epilepsy: an infectious etiology?

November 7, 2001
Stommel, E. W., Seguin, R., Thadani, V. M., Schwartzman, J. D., Gilbert, K., Ryan, K. A., Tosteson, T. D., Kasper, L. H.
Epilepsia 2001; 42: 436-438
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Purpose: Cryptogenic epilepsy, the group of epilepsy syndromes for which an etiology is unknown, comprises similar to 20% of all epilepsy syndromes. We selected patients in this subgroup of epilepsy and tested them for evidence of Toxoplasma gondii IgG antibodies by the enzyme-linked immunosorbent assay. T. gondii is found in up to 20% of the U.S. population forming dormant brain cysts in the latent bradyzoite form. We investigated the hypothesis that dormant T. gondii infection might be associated with cryptogenic epilepsy. Methods: We selected patients with cryptogenic epilepsies and tested them for evidence of T. gondii IgG antibodies by the enzyme-linked immunosorbent assay. A control group was also tested for comparison. Results: We have found a statistically-significant elevation of T. gondii antibodies among cryptogenic epilepsy patients as compared to controls [59% increase in optical density (OD), p = 0.013]. This association persisted after adjustment for subjects' gender and age in a multiple logistic regression model; however, it was no longer as statistically significant. Conclusions: Our results suggest that chronic T. gondii infection with brain cysts may be a cause of cryptogenic epilepsy.

Tagged: bradyzoite, cryptogenic epilepsy, encephalitis, Epidemiology, host-parasite relationship, minnesota, parasitic infections, population, rochester, seizures, Toxoplasma gondii

Physical health

Relationship of central nervous system neoplasms to Toxoplasma gondii infection

November 9, 1967
Schuman LM, Choi NW, Gullen WH
. American Journal of Public Health and the Nations Health 1967; 57: 848-&.
Tagged: adolescent, adult, aged, brain neoplasms/*epidemiology/*etiology, child, female, humans, infant, male, middle aged, minnesota, preschool, spinal cord neoplasms/*epidemiology/*etiology, toxoplasmosis/blood/*complications

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