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Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

etiopathogenesis

Infectious agents and gene-environmental interactions in the etiopathogenesis of schizophrenia

October 30, 2006
Yolken RH, Torrey EF
Clinical Neuroscience Research 2006; 6: 97-109.
Click for abstract
Schizophrenia is a pervasive neuropsychiatric disorder with worldwide prevalence. Family and adoption studies indicate a strong genetic component of disease susceptibility. However, epidemiological studies also point to a role for infections and other environmental factors in disease etiology. We review the evidence for a role for infectious agents in the etiopathogenesis of schizophrenia and related disorders, focusing on the apicomplexan parasite Toxoplasma gondii. We discuss the epidemiological evidence for a role for this agent, as well as potential mechanisms of gene-environmental interactions which are consistent with the genetic components of disease susceptibility. We describe how the potential role of infections as causative agents of complex disorders such as schizophrenia are not consistent with classical postulates of causation such as the Koch Postulates, but may be consistent with more modern concepts of how infectious agents can interact with genetic determinants to result in disease in susceptible individuals. We outline the research approaches which are necessary to define associations between infectious agents and complex disorders. The successful association between infectious agents and diseases such as schizophrenia might lead to new methods for treatment and prevention of these devastating disorders. (C) 2006 Association for Research in Nervous and Mental Disease. Published by Elsevier B.V. All rights reserved.

Tagged: adult schizophrenia, bipolar disorder, etiopathogenesis, helicobacter-pylori-infection, human endogenous retroviruses, in-vivo, nervous-system infections, recent-onset schizophrenia, Schizophrenia, simplex-virus type-1, Toxoplasma gondii, viral encephalitis

Mental health

Infectious agents and gene-environmental interactions in the etiopathogenesis of schizophrenia

March 26, 2006
Yolken, R. H., Torrey, E. F.
Clinical Neuroscience Research 2006; 6: 97-109
Click for abstract
Schizophrenia is a pervasive neuropsychiatric disorder with worldwide prevalence. Family and adoption studies indicate a strong genetic component of disease susceptibility. However, epidemiological studies also point to a role for infections and other environmental factors in disease etiology. We review the evidence for a role for infectious agents in the etiopathogenesis of schizophrenia and related disorders, focusing on the apicomplexan parasite Toxoplasma gondii. We discuss the epidemiological evidence for a role for this agent, as well as potential mechanisms of gene-environmental interactions which are consistent with the genetic components of disease susceptibility. We describe how the potential role of infections as causative agents of complex disorders such as schizophrenia are not consistent with classical postulates of causation such as the Koch Postulates, but may be consistent with more modern concepts of how infectious agents can interact with genetic determinants to result in disease in susceptible individuals. We outline the research approaches which are necessary to define associations between infectious agents and complex disorders. The successful association between infectious agents and diseases such as schizophrenia might lead to new methods for treatment and prevention of these devastating disorders. (C) 2006 Association for Research in Nervous and Mental Disease. Published by Elsevier B.V. All rights reserved.

Tagged: adult schizophrenia, bipolar disorder, etiopathogenesis, helicobacter-pylori-infection, human endogenous retroviruses, in-vivo, nervous-system infections, recent-onset schizophrenia, Schizophrenia, simplex-virus type-1, Toxoplasma gondii, viral encephalitis

Mental health

Topics

  • Behavior 105
  • Cognitive functions 64
  • Mental health 439
  • Morphology 6
  • Motor functions 10
  • Personality 36
  • Physical health 134
  • Reproduction 36
  • Reviews 40
  • Sensory functions 3
  • Uncategorized 2

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