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Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

dendritic cells

Neurophysiological changes induced by chronic Toxoplasma gondii Infection.

March 13, 2017
Tedford, E., McConkey, G.
Pathogens. 2017; 6: 19-31
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Although the parasite Toxoplasma gondii is one of the most pervasive neurotropic pathogens in the world, the host-parasite interactions during CNS infection and the consequences of neurological infection are just beginning to be unraveled. The chronic stages of infection have been considered dormant, although several studies have found correlations of infection with an array of host behavioral changes. These may facilitate parasite transmission and impact neurological diseases. During infection, in addition to the presence of the parasites within neurons, host-mediated neuroimmune and hormonal responses to infection are also present. T. gondii induces numerous changes to host neurons during infection and globally alters host neurological signaling pathways, as discussed in this review. Understanding the neurophysiological changes in the host brain is imperative to understanding the parasitic mechanisms and to delineate the effects of this single-celled parasite on health and its contribution to neurological disease.

Tagged: alzheimers-disease, bipolar disorder, catecholamine, central-nervous-system, dendritic cells, dependent manner, DNA, Dopamine, gamma-interferon, gene-expression, glutamatergic, host-parasite interaction, immune system, infection, methylation, neuroimmune, Neurophysiology, parasitic, testosterone, Toxoplasma gondii

Mental health

Toxoplasmosis gondii infection and diabetes mellitus type 2 treated by using autologous peripheral blood stem cells a unique case report of a caucasian 83 year old lady

January 9, 2015
Gargiulo, C., Pham, V. H., Nguyen, K. C. D., Kim, N. D., Van, T. N., Tuan, A. L., Abe, K., Shiffman, M.
Biomedical Research and Therapy 2015; 2: 339-346
Click for abstract
Introduction: Toxoplasma gondii is an intracellular protozoan responsible for up to one-third of the world's population infestation. Diabetes is one of the most silent and threatening disease of the modern time it is constantly increasing in both industrialized and developing countries. This is a case of clinically importance for two reason, firstly it will help clinicians save a broad differential diagnosis when attending to evaluate analogous cases and secondly, it may confirm the role of autologous peripheral blood stem cells (PB-SCs) in enhancing auto-immune response against parasitic infection and in regulating insulin uptake in diabetes mellitus type 2 (DM2). Case presentation: We present a unique case of 83-year-old woman from Argentina presenting with a widespread erythema and urticaria for 5 months and DM2 as underlying condition. She was initially diagnosed with unspecific skin auto-immune disorder. By the time of visit she was complaining of constant diarrhea-constipation and general mental and physical fatigue. Conclusion: This case illustrates that toxoplasmosis can present with just simple disseminated and generalized skin erythema with severe itching and, thus can be confused with similar infectious disease such as Epstein-Barr virus (EBV), cytomegalovirus, cat scratch disease or leishmaniasis. The report emphasizes the need of correct diagnostic procedure in confusing cases, and may help to increase the awareness about the identification of this disease. This case may open to the possibility of a different approach and methodology in treatment T gondii and DM2 through the use of PB-SCs.

Tagged: bone-marrow-transplantation, cancer, cd3, cd4, cd8, chemotherapy, common variable immunodeficiency, dendritic cells, human peripheral blood stem cells, insulin-producing cells, lung, manipulation., nk cells, patient, randomized-trial, Toxoplasma gondii

Physical health

Topics

  • Behavior 105
  • Cognitive functions 64
  • Mental health 439
  • Morphology 6
  • Motor functions 10
  • Personality 36
  • Physical health 134
  • Reproduction 36
  • Reviews 40
  • Sensory functions 3
  • Uncategorized 2

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Recent articles

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