antibodies – Page 2 – Toxoplasma gondii & Human Phenotype

Cognitive deterioration among bipolar disorder patients infected by Toxoplasma gondii is correlated to interleukin 6 levels

October 6, 2015 85 Comments
Hamdani, N., Daban-Huard, C., Lajnef, M., Gadel, R., Le Corvoisier, P., Delavest, M., Carde, S., Lepine, J. P., Jamain, S., Houenou, J., Galeh, B., Richard, J. R., Aoki, M., Charron, D., Krishnamoorthy, R., Yolken, R., Dickerson, F., Tamouza, R., Leboyer, M.
Journal of Affective Disorders 2015; 179: 161-166

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Is there any role of latent toxoplasmosis in schizophrenia disease?

October 6, 2015 29 Comments
Karabulut, N., Bilgic, S., Gurok, M. G., Karaboga, F.
Journal of the Chinese Medical Association 2015; 78: 533-537

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The relationship between pediatric obsessive compulsive disorder and Toxoplasma gondii

October 6, 2015 46 Comments
Memik, N. C., Tamer, G. S., Unver, H., Gundogdu, O. Y.
Journal of Obsessive-Compulsive and Related Disorders 2015; 7: 24-28

Toxoplasma gondii seropositivity is negatively associated with multiple sclerosis

October 6, 2015 Leave a Comment
Stascheit, F., Paul, F., Harms, L., Rosche, B.
Journal of Neuroimmunology 2015; 285: 119-124

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Immune alterations in acute bipolar depression

May 28, 2015
Dickerson, F., Katsafanas, E., Schweinfurth, L. A. B., Savage, C. L. G., Stallings, C., Origoni, A., Khushalani, S., Lillehoj, E., Yolken, R.
Acta Psychiatrica Scandinavica 2015; 132: 204-210

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An observational study of inflammation in the central nervous system in patients with bipolar disorder

January 5, 2015
Stich, O., Andres, T. A., Gross, C. M., Gerber, S. I., Rauer, S., Langosch, J. M.
Bipolar Disorders 2015; 17: 291-302

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The effect of artemether on psychotic symptoms and cognitive impairment in first-episode, antipsychotic drug-naive persons with schizophrenia seropositive to Toxoplasma gondii

October 10, 2014 206 Comments
Wang, H. L., Xiang, Y. T., Li, Q. Y., Wang, X. P., Liu, Z. C., Hao, S. S., Liu, X., Liu, L. L., Wang, G. H., Wang, D. G., Zhang, P. A., Bao, A. Y., Chiu, H. F. K., Ungvari, G. S., Lai, K. Y. C., Buchanan, R. W.
Journal of Psychiatric Research 2014; 53: 119-124

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Inflammatory molecular signature associated with infectious agents in psychosis

October 9, 2014 32 Comments
Hayes, L. N., Severance, E. G., Leek, J. T., Gressitt, K. L., Rohleder, C., Coughlin, J. M., Leweke, F. M., Yolken, R. H., Sawa, A.
Schizophrenia Bulletin 2014; 40: 963-972

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Association between latent toxoplasmosis and major depression, generalised anxiety disorder and panic disorder in human adults

October 9, 2014 Leave a Comment
Gale, S. D., Brown, B. L., Berrett, A., Erickson, L. D., Hedges, D. W.
Folia Parasitologica 2014; 61: 285-292.

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Relationship between Toxoplasma gondii infection and bipolar disorder in a French sample

October 11, 2013 86 Comments
Hamdani, N., Daban-Huard, C., Lajnef, M., Richard, J. R., Delavest, M., Godin, O., Le Guen, E., Vederine, F. E., Lepine, J. P., Jamain, S., Houenou, J., Le Corvoisier, P., Aoki, M., Moins-Teisserenc, H., Charron, D., Krishnamoorthy, R., Yolken, R., Dickerson, F., Tamouza, R., Leboyer, M.
Journal of Affective Disorders 2013; 148: 444-448

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Prevalence of Toxoplasma gondii infection among individuals with severe mental illness in Nigeria: a case control study

October 11, 2013 118 Comments
James, B. O., Agbonile, I. O., Okolo, M., Lawani, A. O., Omoaregba, J. O.
Pathogens and Global Health 2013; 107: 189-193

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Differences in some developmental features between Toxoplasma gondii-seropositive and seronegative school children

October 9, 2013 33 Comments
Mizgajska-Wiktor, H., Jarosz, W., Andrzejewska, I., Krzykala, M., Janowski, J., Kozlowska, M.
Folia Parasitologica 2013; 60: 416-424

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Prevalence of Toxoplasma gondii parasite infection among people who died due to sudden death in the capital city of Warsaw and its vicinity

September 4, 2013
Samojlowicz, D., Borowska-Solonynko, A., Golab, E.
Przegled Epidemiologicny 2013; 67: 29-33

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BACKGROUND: It has recently been shown that the behavioural effects resulting from latent T. gondii infection in immunocompetent people could pose as a threat to their welfare. AIM. The aim of the study was to evaluate the prevalence of T. gondii infection in a group of people who died suddenly in Warsaw and its vicinity. MATERIAL AND METHODS: The studied group (n = 169 people) included 42 road traffic accident victims who were driving a vehicle (bicycle (n = 6), a motorbike (n = 3), a motorcycle (n = 13), a car (n = 20)) prior to sudden death and 41 people whose death resulted from suicide. Blood samples were collected post-mortem and examined for the presence of T. gondii, IgG antibodies and ethyl alcohol. RESULTS: Of the 169 people tested, T. gondii IgG antibodies were found in the serum of 93 (55%) of which 25 (59.5%) were drivers and 26 (63.4%) people who died as a result of suicide. With respect to the prevalence of T. gondii infection no statistically significant differences were found between the study (61.4%) and control group (49.4%); (p = 0.09). A statistically significant result was recorded in the 38-58 age group between suicide and control groups (71.4% vs. 44.4%; p < 0.05). Positive test results for the presence of ethyl alcohol in the blood were reported among 49.7% of the studied population: 25.7% among drivers, 67.6% among suicides and 51.8% in the control group. To a statisctically siginificant degree, IgG T. gondii antibodies were found to occur more frequently in people with positive blood alcohol test results among suicides (72% vs. 50%; p < 0.05) and among the control group (60% vs. 40%; p < 0.05) than in their equivalents with negative test results. CONCLUSIONS: Our work confirmed the usefulness of serologically testing samples collected post-mortem for epidemiological purposes. The small size of the study group made it impossible to evaluate the potential associations between exposure to T. gondii infection and the probability of sudden death. The significance of Toxoplasma gondii infection as a risk factor for self-destructive behaviour merits further study.

High seroprevalence of Toxoplasma gondii infection in a subset of Mexican patients with work accidents and low socioeconomic status

October 16, 2012
Alvarado-Esquivel, C., Torres-Castorena, A., Liesenfeld, O., Estrada-Martinez, S., Urbina-Alvarez, J. D.
Parasites & Vectors 2012;5: Artn 13 10.1186/1756-3305-5-13

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BACKGROUND: Toxoplasma gondii has been associated with reflex impairment and traffic accidents. It is unknown whether Toxoplasma infection might be associated with work accidents. Therefore, using a case-control seroprevalence study design, 133 patients with a recent work accident and 266 control subjects of the general population from the same region were examined with enzyme-linked immunoassays for the presence and levels of anti-Toxoplasma IgG antibodies and anti-Toxoplasma IgM antibodies. Socio-demographic, work, clinical and behavioral characteristics from each worker were obtained. RESULTS: Eleven (8.3%) of 133 patients, and 14 (5.3%) of 266 controls had anti-T. gondii IgG antibodies. Anti-T. gondii IgG levels were higher than 150 IU/ml in 8 (6%) patients and 10 (3.8%) controls. Anti-T. gondii IgM antibodies were found in one (0.8%) of the workers, and in 6 (2.3%) of the controls. No statistically significant differences in the IgG seroprevalences, frequencies of high IgG levels, and IgM seroprevalences among patients and controls were found. In contrast, a low socio-economic level in patients with work accidents was associated with Toxoplasma seropositivity (P = 0.01). Patients with work accidents and low socioeconomic status showed a significantly (OR = 3.38; 95% CI: 0.84-16.06; P = 0.04) higher seroprevalence of T. gondii infection than controls of the same socioeconomic status (15.1% vs. 5%, respectively). Multivariate analysis showed a positive association of T. gondii infection with boar meat consumption (OR = 3.04; 95% CI: 1.03-8.94; P = 0.04). In contrast, a negative association between T. gondii infection and national trips (OR = 0.40; 95% CI: 0.17-0.96; P = 0.04), sausage consumption (OR = 0.20; 95% CI: 0.05-0.68; P = 0.01), and ham consumption (OR = 0.16; 95% CI: 0.05-0.51; P = 0.002) was found. CONCLUSIONS: In the study described here seropositivity to T. gondii was associated to work accidents in a subset of patients with low socioeconomic status. This is the first report of an association of T. gondii infection and work accidents. Further studies to confirm our results are needed. Results may help in designing optimal prevention strategies to avoid T. gondii infection.

Seroprevalence of anti-Toxoplasma gondii IgG antibody in patients with schizophrenia

October 16, 2012
Emelia, O., Amal, R. N., Ruzanna, Z. Z., Shahida, H., Azzubair, Z., Tan, K. S., Aadila, S. N., Siti, N. A. M., Aisah, M. Y.
Tropical Biomedicine 2012; 29: 151-159

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Does Toxoplasma gondii infection affect cognitive function? A case control study

October 16, 2012
Guenter, W., Bielinski, M., Deptula, A., Zalas-Wiecek, P., Piskunowicz, M., Szwed, K., Bucinski, A., Gospodarek, E., Borkowska, A.
Folia Parasitologica 2012; 59: 93-98.

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Does Toxoplasma gondii play a role in obsessive-compulsive disorder?

October 11, 2012 Leave a Comment
Taboas W, McKay D, Taylor S.
Psychiatry Research 2012; 198: 176-177

Incidence of adult brain cancers is higher in countries where the protozoan parasite Toxoplasma gondii is common

October 11, 2012 13 Comments
Thomas, F., Lafferty, K. D., Brodeur, J., Elguero, E., Gauthier-Clerc, M., Misse, D.
Biology Letters 2012; 8: 101-103

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Toxoplasma gondii and other risk factors for schizophrenia: An update

October 11, 2012 Leave a Comment
Torrey, E.F., Bartko, J.J., Yolken, R.H.
Schizophrenia Bulletin 2012; 38: 642-647

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Toxoplasma infection in schizophrenia patients: A comparative study with control group

October 19, 2011
Alipour, A., Shojaee, S., Mohebali, M., Tehranidoost, M., Masoleh, F. A., Keshavarz, H.
Iranian Journal of Parasitology 2011; 6: 31-37

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Toxoplasma gondii infection and liver disease: a case-control study in a Northern Mexican population

October 19, 2011
Alvarado-Esquivel, C., Torres-Berumen, J. L., Estrada-Martinez, S., Liesenfeld, O., Mercado-Suarez, M. F.
Parasites & Vectors 2011; 4

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Toxoplasma gondii infection and schizophrenia: A case control study in a low Toxoplasma seroprevalence Mexican population

October 19, 2011
Alvarado-Esquivel, C., Urbina-Alvarez, J. D., Estrada-Martinez, S., Torres-Castorena, A., Molotla-de-Leon, G., Liesenfeld, O., Dubey, J. P.
Parasitology International 2011; 60: 151-155

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Could Toxoplasma gondii have any role in Alzheimer disease?

October 19, 2011
Kusbeci, O. Y., Miman, O., Yaman, M., Aktepe, O. C., Yazar, S.
Alzheimer Disease and Associated Disorders 2011; 25: 1-3

Seroprevalence of Toxoplasma gondii infection in female sterility patients in China

October 19, 2011
Alvarado-Esquivel, C., Torres-Berumen, J. L., Estrada-Martinez, S., Liesenfeld, O., Mercado-Suarez, M. F.
Journal of Parasitology 2011; 97: 529-530

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Serum antibodies to Toxoplasma gondii and Herpesvidae family viruses in individuals with schizophrenia and bipolar disorder: a case-control study

October 16, 2011
Tedla, Y., Shibre, T., Ali, O., Tadele, G., Woldeamanuel, Y., Asrat, D., Aseffa, A., Mihret, W., Abebe, M., Alem, A., Medhin, G., Habte, A.
Ethiopian Medical Journal 2011; 49: 211-220

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Potential immunomodulatory effects of latent toxoplasmosis in humans

January 9, 2011
Flegr, J., Striz, I.
Bmc Infectious Diseases 2011; 11: Artn 274 10.1186/1471-2334-11-274

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Toxoplasma infection and later development of schizophrenia in mothers

January 5, 2011
Pedersen, M. G., Stevens, H., Pedersen, C. B., Norgaard-Pedersen, B., Mortensen, P. B
American Journal of Psychiatry 2011;168: 814-821

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Seroepidemiology of Toxoplasma gondii infection in patients with vision and hearing impairments, cancer, HIV, or undergoing hemodialysis in Durango, Mexico.

October 19, 2010
Alvarado-Esquivel, C., Liesenfeld, O., Torres-Castorena, A., Estrada-Martinez, S., Urbina-Alvarez, J. D., Ramos-de la Rocha, M., Marquez-Conde, J. A., Dubey, J. P.
Journal of Parasitology 2010; 96: 505-508.

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Serological survey of Toxoplasma gondii in schizophrenia patients referred to Psychiatric Hospital, Sari City, Iran

October 19, 2010
Daryani, A., Sharif, M., Hosseini, S. H., Karimi, S. A., Gholami, S.
Tropical Biomedicine 2010; 27: 476-482

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Toxoplasmosis as a cause for behaviour disorders – overview of evidence and mechanisms

October 19, 2010
Fekadu A, Shibre T, Cleare AJ.
Folia Parasitologica 2010; 57: 105-113

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The association of infectious agents and schizophrenia

October 19, 2010
Krause, D., Matz, J., Weidinger, E., Wagner, J., Wildenauer, A., Obermeier, M., Riedel, M., Muller, N.
World Journal of Biological Psychiatry 2010; 11: 739-743

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The probable relation between Toxoplasma gondii and Parkinson’s disease

October 19, 2010
Miman, O., Kusbeci, O. Y., Aktepe, O. C., Cetinkaya, Z.
Neuroscience Letters 2010; 475: 129-131

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Possible role of toxoplasmosis in patients with first-episode schizophrenia

October 19, 2010
Tanyuksel, M., Uzun, O., Araz, E., Koru, O., Babur, C.
Turkish Journal of Medical Sciences 2010; 40: 399-404

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The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia – the risk factor or an indication of a contact with cat?

October 19, 2010
Yuksel, P., Alpay, N., Babur, C., Bayar, R., Saribas, S., Karakose, A. R., Aksoy, C., Aslan, M., Mehmetali, S., Kilic, S., Balcioglu, I., Hamanca, O., Dirican, A., Kucukbasmaci, O., Oner, A., Torun, M. M., Kocazeybek, B.
Folia Parasitologica 2010; 57: 121-128

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Toxoplasma gondii infection in first-episode and inpatient individuals with schizophrenia

January 9, 2010
Hamidinejat, H., Ghorbanpoor, M., Hosseini, H., Alavi, S. M., Nabavi, L., Jalali, M. H., Borojeni, M. P., Jafari, H., Mohammadaligol, S.
International Journal of Infectious Diseases 2010; 14: E978-E981

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Toxoplasma gondii antibody titers and history of suicide attempts in patients with recurrent mood disorders

October 30, 2009
Arling, T. A., Yolken, R. H., Lapidus, M., Langenberg, P., Dickerson, F. B., Zimmerman, S. A., Balis, T., Cabassa, J. A., Scrandis, D. A., Tonelli, L. H., Postolache, T. T.
The Journal of Nervous and Mental Disease 2009; 3:905-908

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Schizophrenia and toxoplasmosis

October 26, 2009
Dion, S., Barbe, P. G., Leman, S., Camus, V., Dimier-Poisson, I.
M S-Medecine Sciences 2009; 25: 687-691.

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A possible relationship between Toxoplasma gondii and schizophrenia: A seroprevalence study

October 26, 2009
Dogruman-Al, F., Aslan, S., Yalcin, S., Kustimur, S., Turk, S.
International Journal of Psychiatry in Clinical Practice 2009; 13: 82-87.

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Higher prevalence of toxoplasmosis in victims of traffic accidents suggest increased risk of traffic accident in Toxoplasma-infected inhabitants of Istanbul and its suburbs.

October 26, 2009
Kocazeybek, B., Oner, Y. A., Turksoy, R., Babur, C., Cakan, H., Sahip, N., Unal, A., Ozaslan, A., Kilic, S., Saribas, S., Asian, M., Taylan, A., Koc, S., Dirican, A., Uner, H. B., Oz, V., Ertekin, C., Kucukbasmaci, O., Torun, M. M.
Forensic Science International 2009; 187: 103-108

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Reflexes of drivers who have toxoplasmosis have been shown to deteriorate from the actions of the parasitic cysts. The cysts can change the level of the neurotransmitters such as dopamine in the brain and by doing so extend the muscle response time and change personality profiles. In this Study, we aimed to determine the frequency of the latent toxoplasmosis (LT) in the driver population who were either injured or died in traffic accidents reported in Istanbul and its suburbs. We compared the results with a control group and discussed the relationship between the LT and the traffic accidents. We included 218 (89.7%) non-fatal, 25 (10.3%) fatal cases in our study as study groups. A total 243 subjects, 234 (96%) male, 9 (4%) female (who were alcohol negative) compared with 191 (95.5%) male and 9 (4.5%) female Subjects (control group) who had a traffic accident before but no history of toxoplasmosis were studied. Serologic tests, enzyme immunoassay (EIA) for IgG and IgM, and microimmunoflorescence (MIF) for IgG were used as the reference test, the Sabin-Feldman Dye test (SFDT) was used. According to serologic test results, LT seroprevalence in the study groups was 130 (53.5%) and in the control group 56 (28%) (p < 0.0001). A LT was present in 126 out of 234 (53.8%) males in the study groups, and 54 out of 191 (28.3%) males in the control group (p < 0.0001). In the 31-44 year age group, there was a significant difference with regard to toxoplasmosis between the study subjects and control groups (p < 0.0001). This difference was statistically very significant in (recent and former) cases with middle-aged men (31 44 years old). The results of this retrospective study Suggest that LT in drivers, especially those who are between 31 and 44 years might increase the risk for getting involved in a car accident. In a prospective study, Toxoplasma positive and negative subjects can be monitored before they are involved in a traffic accident to clarify the cause and result relationship. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

Selected infectious agents and risk of schizophrenia among U.S. military personnel

October 29, 2008
Niebuhr, D. W., Millikan, A. M., Cowan, D. N., Yolken, R., Li, Y., Weber, N. S.
The American Journal of Psychiatry 2008;1 65: 99-106

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