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Toxoplasma gondii & Human Phenotype

Compendium of Known Effects and Ongoing Research

anti-toxoplasma igg

A possible relationship between Toxoplasma gondii and schizophrenia: A seroprevalence study

October 26, 2009
Dogruman-Al, F., Aslan, S., Yalcin, S., Kustimur, S., Turk, S.
International Journal of Psychiatry in Clinical Practice 2009; 13: 82-87.
Click for abstract
Objective. Schizophrenia is a pervasive neuropsychiatric disease of uncertain etiology. We aimed to investigate a possible association between Toxoplasma gondii infection and schizophrenia in this study. Method. We selected individuals with schizophrenia (n=88) and tested them with commercially available enzyme-linked immunosorbent assay (ELISA) for anti-Toxoplasma IgG and IgM antibodies and compared these seropositivity rate to those of controls without psychiatric disease (n=88). Results. The rate of IgG antibody in the schizophrenia patients (47.7%) was higher than the control groups (20.4%) (P0.001). We did not find any anti-Toxoplasma IgM seropositivity in both schizophrenia patients and control group. In schizophrenic patients with and without anti-Toxoplasma IgG groups statistical analysis did not reveal any correlation between demographic variables and Toxoplasma infection. Conclusion. Our findings supported previous studies indicate that T.gondii may play a role in etiopathogenesis in some cases of schizophrenia.

Tagged: 1st-episode schizophrenia, anti-toxoplasma igg, anti-toxoplasma igm, antibodies, association, behavior, bipolar disorder, brain, exposure, individuals, infection, necrosis-factor-alpha, Schizophrenia, Toxoplasma gondii

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